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If I have my attack power > than the enemies defence power, or in other words the majority of my attacks are good ones. Do I want to feed the rest of my points into strength/agility(based on weapon) for damage? Is the idea that you want the minimum amount of attack power to get by or did I miss something?
Not sure anyone really knows the answer to that, but if your enemy is stacking a lot of defense you'll need to overcome it somehow and the way to do that is likely stacking attack power or having a lot of str/agi.
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I've never heard of the kill rank/kill protection stat. Is it exclusive to high level gear and even then really rare?
Only on top gear.
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If I was tuning attacks per round for the arena. Is the amount I get always the same regardless of the enemies stats? Could I say tune that in tavern quests?
Your activity level, fighting style and weapon are the strongest factors for your number of attacks.
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Is the amount of blood lust I choose after getting the amount of attacks per round I want purely an endurance based decision or is there a sweet spot for endurance to damage?
There is a sweet spot for each gladiator given their stats, equipment and build, much of the fun is finding it.